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Q: My 71-year-old father began taking Coumadin after a pulmonary embolism a few years ago. Not too long after, he began having more confusion. After going to many more doctors and getting more medicine for dementia and depression — that also cause confusion — there is no definite diagnosis. In fact, he’s getting worse. Is it possible that the Coumadin is causing this?
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The Trusted Source
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Howard LeWine, M.D.

Howard LeWine, M.D., is chief editor of Internet Publishing, Harvard Health Publications. He is a clinical instructor of medicine at Harvard Medical School and Brigham and Women's Hospital. Dr. LeWine has been a primary care internist and teacher of internal medicine since 1978.

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March 29, 2012
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A:

It’s unlikely that the Coumadin (warfarin) is causing the confusion. But I like your idea that one or more of his medicines may be contributing to his symptoms.

My own approach is to stop as many medicines as possible when an older person becomes more confused. But you can’t stop some medicines that he absolutely needs. It would be too dangerous or raise the risk of making other symptoms worse.

In your father’s case, it’s an easy choice to stay on Coumadin. He’s had a life-threatening condition that requires a blood thinner. And Coumadin isn’t usually associated with confusion.

I suggest reviewing all his medicines with his primary care doctor during the next office visit.

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